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Gadbury GL, Garrett KA, Allison DB. Challenges and approaches to statistical design and inference in high dimensional investigations. In: Belostotsky DA Plant Systems Biology, Methods in Molecular Biology Series. Plant Systems Biology, Methods in Molecular Biology Series. Totowa, NJ: The Humana Press Inc; 2009:181 -206. doi:10.1007/978-1-60327-563-7_9.